All good things must come to an end eventually.. so Oprah Winfrey fans circle the calendar, set the DVR – and get out the tissues. The final original episode of “The Oprah Winfrey Show” has been set. May 25 is the big day. Winfrey announced last fall that she would be ending the show after 25 years. She since has launched cable’s Oprah Winfrey Network. The show has been in reruns the past few weeks. But new episodes will start up again next week.